The infectivity of pathogenic aerosols is a critical factor for aerosol transmission of airborne pathogens and diseases. Among the key variables that could cause changes in viral aerosol infectivity, aerosol pH is recognized for its effects on the natural infectivity decay rate of various viral aerosols. (Longest, 2024) However, how pH can potentially affect the efficiency of an engineered inactivation process is less examined. Studies have shown that the effectiveness of disinfection is affected by the liquid substrate pH for viral aerosols deposited on respirators. (Rockey, 2020) It is plausible that viral aerosol pH could also affect engineered inactivation methods, such as non-thermal plasma (NTP) exposure, whose well-documented virucidal effects rely on the highly oxidative species it produces.  We have demonstrated that the presence of gaseous ammonia and hydrogen sulfide can negatively affect the NTP inactivation efficiency of viral aerosols. (Ma, 2024) This study aims to further investigate the role of trace gaseous air contaminants with aerosol-pH-altering potential, in addition to their previously discussed roles in the redox chemistry. Preliminary results indicate exposure to NTP produces a statistically significant change in pH of the media used to collect virus-containing aerosols. By comparing the pH of collected aerosols in the presence of different gaseous species with and without NTP exposure, the role of pH-altering gases can be better understood. Besides, examining and cross-comparing the NTP inactivation efficiency in response to changes in the aqueous pH of viral aerosols could provide additional insights into the role of pH in engineering inactivation processes.