The November 1999 issue of Microbiology Today focuses on genomics, a very hot topic that offers exciting potential for solving microbiological problems in the next thousand years. Microbial sequencing is proceeding space, with new genomes being announced almost monthly. Analysing the resultant wealth of information is down to bioinformaticists. In a range of articles, geneticists and computer experts describe the techniques and applications of microbial genomics and explore some of the exciting future opportunities that this knowledge will bring.