Hepatitis A virus (HAV) is a unique, liver-tropic picornavirus that has not been as widely studied as many other picornaviruses, despite having a significant impact on global health. Highly effective and safe vaccines are available, yet their use is not universal and since 2016 the US alone has seen over 24,000 hospitalisations and 400 deaths due to Hepatitis A. Currently there’s no treatment available for severe cases other than liver transplantation, but research at the University of North Carolina at Chapel Hill supervised by Prof. Stanley M. Lemon has identified an essential step in HAV infection, a finding which offers hope for the development of future therapeutics.