Save the date: Protein Secretion at the Host-Pathogen Interface
Bacterial infections remain one of the top causes of human suffering and death globally. Rising antibiotic resistance is threatening our ability to fight infections and to enhance the burden of disease. Nearly all important bacterial pathogens depend on secretion systems for their ability to cause disease. These systems deliver virulence factors to the surface or directly into host cells, where they modulate host processes to the benefit of the bacteria.
Recent major technical advances in super-resolution light and electron microscopy as well as new ‘omic’-technologies, e.g. chemical and interaction proteomics, are accelerating the functional characterisation of the secretion machineries and their substrates in bacterial pathogenesis. It is therefore an exciting time with new discoveries constantly pushing our understanding of the molecular basis of host-pathogen interactions to new levels.
In this meeting taking place on the 3–4 November 2022 in Belfast, UK, we will bring together world-leading experts on the structure and function of secretion systems as well as their protein cargos from diverse bacteria in Gram-negative and Gram-positive pathogens, providing the audience with an overview of the latest developments and fostering critical exchange, networking and new collaborations across the research community, which investigates protein secretion at the host-pathogen interface.
Key topics
- Structure & function of type II, III, IV, VI and VII secretion systems
- The functional biology and role of secreted/translocated effectors in the interaction with host cells and pathogenesis
- Evolution of secretion systems and effectors
- Methods to identify and functionally characterise new secretion systems and their cargos
Further details regarding the programme will be updated in due course via the event page. Keep up to date by following us on Twitter @MicrobioSoc using the hashtag #HostPathSecretion22
Image: STEVE GSCHMEISSNER / SCIENCE PHOTO LIBRARY
